In our database, we have conducted in-depth research on the core enhancers involved in the developmental processes of both humans and mice, aiming to provide comprehensive data resources for researchers in this field. We have extensively collected data from two species (human and mouse), across three developmental stages (embryo, postnatal, and childhood), spanning four data types, and integrated public data from 109 different tissues, including 20 developmental processes. Within this rich dataset, we have successfully identified 538,461 core enhancers and explored their associations with 20,237 genes and 300 transcription factors. To delve deeper into the functionality of these core enhancers, we have performed gene ontology and pathway analyses, as well as protein-protein interaction analyses, culminating in the integration of 6,811,087 regulatory relationships. Additionally, we provide information on the distribution of shared enhancers during development and differences in H3K27ac signal, as well as detailed data on gene and transcription factor expression, annotation, and distribution of transcription factor binding sites during development. This unique and comprehensive database not only offers valuable resources for researchers studying enhancer regulation mechanisms during development but also provides them with new avenues to explore and understand developmental biology.