People

Principal Investigator

PH.D ZUO YONGCHUN

Yongchun Zuo, Ph.D. Principal Investigator of Bioinformatics. He is one bioinformatics professor of state key laboratory of reproductive regulation and breeding of grassland livestock in Inner Mongolia University. Professor Zuo focuses on the computational biology researches, including classification of DNA/Protein sequence, codon optimization of gene and its regulatory sequence, and integration analysis of multi-omics in cell reprogramming. Classification of DNA/Protein sequence involves identification of important regulatory regions, such as enhancers, promoter and specific protein family by combining machine learning methods and expression omics data. The codon optimization of gene and its regulatory sequence mainly aims to design optimization gene sequence for tissue-specific expression or targeted integration based on sequence optimization. For integration analysis of multi-omics, we aim to establish the bioinformatics landscape of mammalian embryogenesis, explore effective biomarker or epigenetic signature of cell reprogramming, and develop better matching learning model for predicting cell fate determination and cell differentiation. Recently, we successfully performed systematic comparisons based on differential co-expression analysis for preimplantation development, and develop the first database for exploring time activation of gene expression in mammalian embryos.

Email ：yczuo@imu.edu.cn Tel ：0471-5227683

Staff

PH.D XI QILEMUGE

Qilemuge Xi, Ph.D. laboratory technician, research direction is bioinformatics. Recently, she has been mainly engaged in the bioinformatics mining of tumor immune microenvironment related characteristics based on multi-omics big data. She has successively constructed relatively comprehensive breast cancer data and metabolic cell label genomic data, systematically analyzed the molecular subtype model of breast cancer, the gene modules of different subtypes, and explored the relationship between breast cancer immune subtypes and endogenous and exogenous immune escape. It was found that the ABCB1 gene plays an important role in the tumor-infiltrating immune microenvironment of breast cancer. The relevant research results have been published in bioinformatics SCI journals such as Nucleic Acids Research, Briefings in Bioinformatics, Cell&Bioscience, Methods, Molecular Therapy-Nucleic Acids, etc.

Email ：qlmgxi@imu.edu.cn

PH.D Cong Shan

Shan Cong, Ph.D. senior laboratory technician, research direction is animal cell biology and animal physiology. Recently, she has been mainly engaged in the mining of genetic variants and genes related to multi-vertebrae in Mongolian sheep based on multi-omics data. Focusing on Mongolian sheep populations with significant phenotypic differences, she integrates genomic, transcriptomic, epigenomic, and metabolomic data to construct a systematic analysis framework linking “genotype–phenotype–regulatory mechanisms,” ultimately identifying the key factors underlying multi-vertebrae formation. She is also responsible for teaching the courses Cell Engineering Experiment and Animal Physiology, and serves concurrently as a graduate student counselor.

Email ：315551470@qq.com